Current Strategies for The Disruption and Inhibition of Oral Biofilm Formation

Oral biofilm, an organized community comprises of extensive variety microbes rooted with extracellular polysaccharides (EPS) matrix. It is recognized as a virulence factor to numerous oral infectious diseases including dental caries, gingivitis, periodontitis, periapical periodontitis and peri-implantitis [1]. Biofilm formation on medical devices such mechanical heart valves, catheters, contact lenses prosthetic joints pose critical problem. Both gram positive negative bacteria can form biofilms devices. Medical device infections are accountable for almost 60% hospital acquired infections. In the United States, anticipated expense caring healthcare-associated nearly between $28 billion $45 each year [2]. The lifecycle conventional biofilm bacterial attachment, growth/maturation, dispersion.